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Educational Literature

Peer-reviewed citations supporting the strengths and combinations we compound most often, organized by condition.

Educational Literature

Acne

Metronidazole 1–2%

Oztürkcan S, Ermertcan AT, Sahin MT, Afşar FS. Efficiency of benzoyl peroxide-erythromycin gel in comparison with metronidazole gel in the treatment of acne rosacea. J Dermatol. 2004 Aug;31(8):610–7. PMID: 15492433

Thiboutot DM. Acne and rosacea. New and emerging therapies. Dermatol Clin. 2000 Jan;18(1):63–71, viii. Review. PMID: 10626112

Lipoic Acid 0.5–1%

Kovalev VM. [Complex treatment of acne with lipoic acid] Vrach Delo. 1981 Mar;(3):108–13. Russian. No abstract available. PMID: 6457447

Niacinamide 3–5%

Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006 Jun;8(2):96–101. PMID: 16766489

Anal Fissures

Amitriptyline 1–2% / Nitroglycerine 0.2–0.25%

Bhardwaj R, Parker MC. Modern perspectives in the treatment of chronic anal fissures. Ann R Coll Surg Engl. 2007 Jul;89(5):472–8. Review. PMID: 17688717

Dhawan S, Chopra S. Nonsurgical approaches for the treatment of anal fissures. Am J Gastroenterol. 2007 Jun;102(6):1312–21. Review. PMID: 17531031

Diltiazem 2%

Shrivastava UK, Jain BK, Kumar P, Saifee Y. A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial. Surg Today. 2007;37(6):482–5. Epub 2007 May 28. PMID: 17522765

Nash GF, Kapoor K, Saeb-Parsy K, Kunanadam T, Dawson PM. The long-term results of diltiazem treatment for anal fissure. Int J Clin Pract. 2006 Nov;60(11):1411–3. Epub 2006 Aug 15. PMID: 16911570

Nifedipine 0.2–0.25%

Katsinelos P, Papaziogas B, Koutelidakis I, Paroutoglou G, Dimiropoulos S, Souparis A, Atmatzidis K. Topical 0.5% nifedipine vs. lateral internal sphincterotomy for the treatment of chronic anal fissure: long-term follow-up. Int J Colorectal Dis. 2006 Mar;21(2):179–83. Epub 2005 Aug 10. PMID: 16091912

Shingles / Neuropathy

Acyclovir 2–6%

Neoh C, Harding SP, Saunders D, Wallis S, Tullo AB, Nylander A, Nelson ME. Comparison of topical and oral acyclovir in early herpes zoster ophthalmicus. Eye. 1994;8(Pt 6):688–91. PMID: 7867830

Ketoprofen 5–20%

No articles on file.

Gabapentin 4–6%

Loosemore MP, Bordeaux JS, Bernhard JD. Gabapentin treatment for notalgia paresthetica, a common isolated peripheral sensory neuropathy. J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1440–1. No abstract available. PMID: 17958872

Várkonyi T, Kempler P. Diabetic neuropathy: new strategies for treatment. Diabetes Obes Metab. 2007 Jun 26; Epub ahead of print. PMID: 17593238

Amitriptyline 1–2%

Ho KY, Huh BK, White WD, Yeh CC, Miller EJ. Topical Amitriptyline Versus Lidocaine in the Treatment of Neuropathic Pain. Clin J Pain. 2008 Jan;24(1):51–55. PMID: 18180637

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